Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects Shin EJ; Lee PH; Kim HJ; Nabeshima T; Kim HCJ Pharmacol Sci 2008[Jan]; 106 (1): 22-7Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to phencyclidine-like dextrorphan is not essential for the neuroprotective activity of dextromethorphan. Here, we review the neuroprotective properties of dextromethorphan and its potential for abuse and the potential neuroprotective effects of the drug's analogs and 3-hydroxymorphinan, a metabolite of dextromethorphan. These compounds may provide a novel therapeutic direction for the treatment of neurodegenerative diseases such as convulsive or parkinsonian-like disorders.|Animals[MESH]|Antitussive Agents/adverse effects/*pharmacology[MESH]|Behavior, Animal/*drug effects[MESH]|Brain Ischemia/drug therapy[MESH]|Central Nervous System/*drug effects[MESH]|Dextromethorphan/adverse effects/*analogs & derivatives/*pharmacology[MESH]|Humans[MESH]|Neuroprotective Agents/adverse effects/*pharmacology[MESH]|Parkinson Disease/drug therapy[MESH]|Seizures/drug therapy[MESH]|Structure-Activity Relationship[MESH]|Substance-Related Disorders/*prevention & control[MESH] |