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lüll HELLP syndrome - a multisystemic disorder Mihu D; Costin N; Mihu CM; Seicean A; Ciortea RJ Gastrointestin Liver Dis 2007[Dec]; 16 (4): 419-24HELLP syndrome is a multisystemic disorder with an incidence of 0.17-0.85% of all pregnancies. Its etiopathogenesis is not completely understood. The most widely accepted hypotheses are: a change in the immune feto-maternal balance, platelet aggregation, endothelial dysfunction, arterial hypertension and an inborn error of the fatty acid oxidative metabolism. Hepatic involvement occurs by intravascular fibrin deposition and hypovolemia. Materno-fetal complications cause a 6.7-70% perinatal mortality rate and a 1-24% maternal mortality rate. The recognition of HELLP syndrome and the rapid initiation of therapy are required for the improvement of materno-fetal prognosis.|*HELLP Syndrome/diagnosis/epidemiology/etiology[MESH]|Biopsy[MESH]|Diagnosis, Differential[MESH]|Diagnostic Imaging/methods[MESH]|Female[MESH]|Humans[MESH]|Liver/pathology[MESH]|Pregnancy[MESH]|Prevalence[MESH]|Prognosis[MESH] |