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lüll Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic Lim JK; Louie CY; Glaser C; Jean C; Johnson B; Johnson H; McDermott DH; Murphy PMJ Infect Dis 2008[Jan]; 197 (2): 262-5West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval CI, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.|*Disease Outbreaks[MESH]|*Genetic Predisposition to Disease[MESH]|Adult[MESH]|Aged[MESH]|California/epidemiology[MESH]|Cohort Studies[MESH]|Female[MESH]|Homozygote[MESH]|Humans[MESH]|Illinois/epidemiology[MESH]|Male[MESH]|Middle Aged[MESH]|Receptors, CCR5/*deficiency/genetics[MESH]|Risk Factors[MESH]|West Nile Fever/*epidemiology/*genetics/physiopathology/virology[MESH]|West Nile virus/*pathogenicity[MESH] |