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VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation Vestweber DArterioscler Thromb Vasc Biol 2008[Feb]; 28 (2): 223-32Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control of endothelial cell contacts. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes.|Adherens Junctions/*physiology[MESH]|Animals[MESH]|Antigens, CD/*physiology[MESH]|Cadherins/*physiology[MESH]|Cell Adhesion/physiology[MESH]|Chemotaxis, Leukocyte/physiology[MESH]|Endothelium, Vascular/physiology[MESH]|Humans[MESH]|Mice[MESH]|Neovascularization, Physiologic/*physiology[MESH]|Signal Transduction[MESH] |
