Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll A functional link between SIRT1 deacetylase and NBS1 in DNA damage response Yuan Z; Seto ECell Cycle 2007[Dec]; 6 (23): 2869-71In mammalian cells, DNA is often subjected to stresses such as ionizing radiation (IR) that can induce DNA double strand breaks (DSBs). In response to DNA DSBs, mammalian cells activate a rapid phosphorylation signaling cascade through the protein kinases, Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-Related (ATR). Many well-characterized DNA repair factors are phosphorylated by ATM in response to DSBs, and the sequential phosphorylation of some of these factors, including NBS1, delay cell cycle progression (checkpoint arrest) to allow time for DNA damage repair. Results from a new study suggest that phosphorylation of NBS1 is regulated by the acetylation status of the protein, which is modulated by SIRT1 deacetylase.|*DNA Repair[MESH]|Acetylation[MESH]|Animals[MESH]|Cell Cycle Proteins/metabolism/*physiology[MESH]|DNA-Binding Proteins[MESH]|Humans[MESH]|MAP Kinase Signaling System[MESH]|Mice[MESH]|Nuclear Proteins/metabolism/*physiology[MESH]|Phosphorylation[MESH]|Sirtuin 1[MESH]|Sirtuins/metabolism/*physiology[MESH] |