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Nuclear factor-kappaB activation: from bench to bedside Sethi G; Sung B; Aggarwal BBExp Biol Med (Maywood) 2008[Jan]; 233 (1): 21-31Nuclear factor-kappaB (NF-kappaB) is a proinflammatory transcription factor that has emerged as an important player in the development and progression of malignant cancers. NF-kappaB targets genes that promote tumor cell proliferation, survival, metastasis, inflammation, invasion, and angiogenesis. Constitutive or aberrant activation of NF-kappa is frequently encountered in many human tumors and is associated with a resistant phenotype and poor prognosis. The mechanism of such persistent NF-kappaB activation is not clear but may involve defects in signaling pathways, mutations, or chromosomal rearrangements. Suppression of constitutive NF-kappaB activation inhibits the oncogenic potential of transformed cells and thus makes NF-kappaB an interesting new therapeutic target in cancer.|Acetylation[MESH]|Anti-Inflammatory Agents/pharmacology[MESH]|Anticarcinogenic Agents/pharmacology[MESH]|Cell Line, Tumor[MESH]|Cell Proliferation[MESH]|Enzyme Inhibitors/pharmacology[MESH]|Humans[MESH]|NF-kappa B/antagonists & inhibitors/*metabolism[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/drug therapy/*metabolism[MESH]|Neovascularization, Pathologic/metabolism[MESH]|RNA Interference[MESH]|Transcriptional Activation/drug effects[MESH] |
