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Special regulatory T-cell review: Regulation of immune responses--examining the role of T cells Simpson EImmunology 2008[Jan]; 123 (1): 13-6The history of regulatory T cells goes back to the realisation that T cells could provide 'help' for antibody responses: the obverse of this is their ability to hold them in check. This brief personal overview follows the initial designation of T cells as 'suppressor' and the various hypotheses, some now disproved, put forward for their mechanism of action. We now cautiously label them T regulatory cells, but realise they do not control not all immune regulation. They probably operate through several mechanisms, and some of these are discussed.|Animals[MESH]|H-2 Antigens/genetics/immunology[MESH]|Immune Tolerance/genetics/*immunology[MESH]|Lymphocyte Cooperation/immunology[MESH]|Mice[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH]|Terminology as Topic[MESH] |
