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Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate: a case report and review of literature Bosman T; Simonin C; Launay D; Caron S; Destee A; Defebvre LRheumatol Int 2008[May]; 28 (7): 713-8Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare clinical entity, characterized by a chronic inflammation causing thickening of the dura. Adequate therapeutic management is still a matter of debate. We present a patient with an IHCP, non-responsive to corticotherapy. Oral methotrexate was introduced (12.5 mg weekly) and total remission was observed after 6 weeks, both clinically and after neuro-imaging. We conclude that methotrexate can be effective and a therapeutical option in patients with IHCP who are resistant to corticotherapy or present major side-effects of chronic corticosteroids use.|Administration, Oral[MESH]|Dura Mater/*pathology[MESH]|Humans[MESH]|Hypertrophy[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Meningitis/diagnosis/*drug therapy/pathology[MESH]|Methotrexate/administration & dosage/*therapeutic use[MESH]|Middle Aged[MESH] |
