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lüll Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system Lieber MR; Lu H; Gu J; Schwarz KCell Res 2008[Jan]; 18 (1): 125-33Nonhomologous DNA end joining (NHEJ) is the primary pathway for repair of double-strand DNA breaks in human cells and in multicellular eukaryotes. The causes of double-strand breaks often fragment the DNA at the site of damage, resulting in the loss of information there. NHEJ does not restore the lost information and may resect additional nucleotides during the repair process. The ability to repair a wide range of overhang and damage configurations reflects the flexibility of the nuclease, polymerases, and ligase of NHEJ. The flexibility of the individual components also explains the large number of ways in which NHEJ can repair any given pair of DNA ends. The loss of information locally at sites of NHEJ repair may contribute to cancer and aging, but the action by NHEJ ensures that entire segments of chromosomes are not lost.|Adaptation, Biological/*genetics[MESH]|Aging/*genetics/physiology[MESH]|Animals[MESH]|DNA Ligase ATP[MESH]|DNA Ligases/genetics/metabolism/*physiology[MESH]|DNA Repair Enzymes/metabolism/physiology[MESH]|DNA Repair/*genetics/physiology[MESH]|DNA-Activated Protein Kinase/metabolism/physiology[MESH]|DNA-Binding Proteins/metabolism/physiology[MESH]|DNA-Directed DNA Polymerase/genetics/*physiology[MESH]|Deoxyribonucleases/genetics/*physiology[MESH]|Endonucleases[MESH]|Humans[MESH]|Immune System/*enzymology/metabolism[MESH]|Immunoglobulin Class Switching/genetics[MESH]|Models, Biological[MESH]|Neoplasms/*enzymology/genetics[MESH]|Nuclear Proteins/metabolism/physiology[MESH]|Recombination, Genetic[MESH]|VDJ Exons/genetics[MESH]|Vertebrates/genetics[MESH] |