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Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?Suri A; Levisetti MG; Unanue ERCurr Opin Immunol 2008[Feb]; 20 (1): 105-10One seminal aspect in autoimmune diabetes is antigen presentation of beta cell antigens by the diabetes-propensity class II histocompatibility molecules. The binding properties of I-Ag7 molecules are reviewed here and an emphasis is placed on their selection of peptides with a highly specific sequence motif, in which one or more acidic amino acids are found at the carboxy end interacting at the P9 anchoring site of I-Ag7. The reasons for the central role of I-Ag7 in the autoimmune response are analyzed. The insulin B chain segment 9-23 is a hot spot for T cell selection and a striking example of a weak MHC binding peptide that triggers autoreactivity.|*Antigen Presentation[MESH]|*Autoimmunity[MESH]|Animals[MESH]|Diabetes Mellitus, Type 1/*immunology[MESH]|Epitopes, T-Lymphocyte/chemistry/immunology[MESH]|Histocompatibility Antigens Class I/*chemistry/metabolism[MESH]|Humans[MESH]|Insulin/chemistry/immunology[MESH]|Mice[MESH]|Peptides/chemistry/*immunology[MESH]|T-Lymphocytes/immunology[MESH] |
