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lüll Optimizing combination treatment in the management of type 2 diabetes Derosa G; Sibilla SVasc Health Risk Manag 2007[]; 3 (5): 665-71Obtaining the suggested glycemic control is the most important achievement in order to prevent cardiovascular complications in patients with type 2 diabetes. Monotherapy often fails after a period of treatment, so that multiple drugs are needed to achieve effective glycemic control. A number of oral glucose lowering drugs is now available such as metformin, sulfonylureas, non-sulfonylureas secretagogues (metiglinides derivatives), alpha-glucosidases inhibitors, and the newest agent: thiazolidinediones (TZD). The possible associations of oral glucose lowering drugs for optimal treatment of type 2 diabetes are briefly reviewed. In particular, the effects of different classes of drugs on cardiovascular risk factors (and particular hypertension and dyslipidemia) and well recognized cardiovascular disease markers in type 2 diabetes are analyzed: in this context TZD appear the more innovative drugs and have been shown to play a key role in the management of hypertension, dyslipidemia, inflammation and endothelial disfunction in diabetic patients. The possible adverse effects derived from the association of different drug classes are also considered.|Cardiovascular Diseases/complications/pathology[MESH]|Diabetes Mellitus, Type 2/*drug therapy[MESH]|Drug Therapy, Combination[MESH]|Humans[MESH]|Hyperglycemia/drug therapy[MESH]|Risk Factors[MESH] |