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Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?Kanoh J; Yanagida MGenes Cells 2007[Dec]; 12 (12): 1301-4A recent paper (Hayashi et al. 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk-2/Rad-5, physically interacts with all the phosphoinositide 3-kinase-related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK-related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.|Cell Cycle Proteins/genetics/*metabolism[MESH]|DNA Replication[MESH]|Phosphatidylinositol 3-Kinases/*physiology[MESH]|Schizosaccharomyces pombe Proteins/genetics/metabolism/*physiology[MESH]|Signal Transduction/physiology[MESH]|Telomere-Binding Proteins/genetics/*metabolism[MESH] |
