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lüll PTPN22: its role in SLE and autoimmunity Chung SA; Criswell LAAutoimmunity 2007[Dec]; 40 (8): 582-90A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.|Animals[MESH]|Arthritis, Rheumatoid/enzymology/genetics/immunology[MESH]|Autoimmunity/*genetics[MESH]|Diabetes Mellitus, Type 1/enzymology/genetics/immunology[MESH]|Humans[MESH]|Lupus Erythematosus, Systemic/enzymology/*genetics/immunology[MESH]|Polymorphism, Genetic/immunology[MESH]|Protein Tyrosine Phosphatase, Non-Receptor Type 22/*genetics/immunology[MESH]|Thyroid Diseases/enzymology/genetics/immunology[MESH] |