Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Hypocretin/Orexin: a molecular link between sleep, energy regulation, and pleasure Ganjavi H; Shapiro CMJ Neuropsychiatry Clin Neurosci 2007[Fal]; 19 (4): 413-9Hypocretin (Hcrt) is a neurotransmitter of the dorsal and lateral hypothalamus that regulates sleep, appetite, and energy consumption. Recent evidence indicates that it is also involved in pleasure/reward-seeking. Mutation of the Hcrt-receptor gene causes narcolepsy in canines, and Hcrt knockout mice exhibit narcolepsy-like symptoms. Human narcoleptics do not commonly have mutations in the ligand or receptor but do have degeneration of Hcrt-containing neurons, possibly through an autoimmune mechanism. When Hcrt neurons degenerate in mice, hypophagia and obesity are observed, symptoms that are also present in some human narcoleptics. This article reviews the recent literature with regard to the many functions of this single molecule. The authors suggest that eating habits and impulsivity may be topics worth exploring in the evaluation of narcoleptic patients.|Appetite/*genetics/*physiology[MESH]|Autonomic Nervous System/physiology[MESH]|Endocrine System/physiology[MESH]|Energy Metabolism/*genetics/*physiology[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/*genetics/*physiology[MESH]|Kleine-Levin Syndrome/physiopathology[MESH]|Neuropeptides/*genetics/*physiology[MESH]|Orexins[MESH]|Prader-Willi Syndrome/physiopathology[MESH]|Sleep/*genetics/*physiology[MESH] |