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  • Regulatory T cells and tumour immunity - observations in mice and men
  • Gallimore A; Godkin A
  • Immunology 2008[Feb]; 123 (2): 157-63
  • An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.
  • |Animals[MESH]
  • |Forkhead Transcription Factors/blood[MESH]
  • |Humans[MESH]
  • |Immune Tolerance[MESH]
  • |Immunotherapy/methods[MESH]
  • |Mice[MESH]
  • |Neoplasms, Experimental/immunology[MESH]
  • |Neoplasms/*immunology/pathology/therapy[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]





  • *{{pmid18067556}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=18067556 Regulatory T cells and tumour immunity - observations in mice and men ]</b> Immunology 2008; 123(2) ; 157-63 Gallimore A; Godkin A

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    Immunology

    157 2.123 2008