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  • Chemical modification: the key to clinical application of RNA interference?
  • Corey DR
  • J Clin Invest 2007[Dec]; 117 (12): 3615-22
  • RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.
  • |*RNA Stability[MESH]
  • |*RNA, Small Interfering/chemistry/pharmacology/therapeutic use[MESH]
  • |Gene Expression Regulation/*drug effects[MESH]
  • |Humans[MESH]
  • |RNA Interference/*drug effects[MESH]

  • *{{pmid18060019}}
    *<b>[ Chemical modification: the key to clinical application of RNA interference?]</b> J Clin Invest 2007; 117(12) ; 3615-22 Corey DR


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    J Clin Invest

    3615 12.117 2007