Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Progress and challenges in selected areas of tobacco carcinogenesis Hecht SSChem Res Toxicol 2008[Jan]; 21 (1): 160-71Tobacco use continues to be a major cause of cancer in the developed world, and despite significant progress in this country in tobacco control, which is driving a decrease in cancer mortality, there are still over 1 billion smokers in the world. This perspective discusses some selected issues in tobacco carcinogenesis focusing on progress during the 20 years of publication of Chemical Research in Toxicology. The topics covered include metabolism and DNA modification by tobacco-specific nitrosamines, tobacco carcinogen biomarkers, an unidentified DNA ethylating agent in cigarette smoke, mutations in the K-RAS and p53 gene in tobacco-induced lung cancer and their possible relationship to specific carcinogens, secondhand smoke and lung cancer, emerging issues in smokeless tobacco use, and a conceptual model for understanding tobacco carcinogenesis. It is hoped that a better understanding of mechanisms of tobacco-induced cancer will lead to new and useful approaches for the prevention of lung cancer and other cancers caused by tobacco use.|Alkylation[MESH]|Animals[MESH]|Biomarkers[MESH]|Carcinogens/chemistry/*toxicity[MESH]|DNA Adducts/drug effects[MESH]|Genes, ras/genetics[MESH]|Humans[MESH]|Lung Neoplasms/chemically induced/genetics[MESH]|Mutation/physiology[MESH]|Nicotiana/chemistry/*toxicity[MESH]|Nitrosamines/chemistry/toxicity[MESH]|Smoke/adverse effects/analysis[MESH]|Tobacco Smoke Pollution/adverse effects[MESH]|Tobacco, Smokeless/adverse effects[MESH] |