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lüll Cancer chemopreventive effects of lactic acid bacteria Kim JE; Kim JY; Lee KW; Lee HJJ Microbiol Biotechnol 2007[Aug]; 17 (8): 1227-35Lactic acid bacteria (LAB) provide several potential health and nutritional benefits, including improving the nutritional value of food, controlling serum cholesterol levels, and controlling some types of cancer. Numerous in vitro, in vivo, human, and epidemiological studies have provided evidence of the chemopreventive effects of LAB on colon, bladder, liver, breast, and gastric cancers. These effects act via diverse mechanisms, including alteration of the gastrointestinal microflora, enhancement of the host's immune response, and antioxidative and antiproliferative activities. This review discusses the recent progresses on the chemopreventive effects of LAB on specific cancer types and the underlying molecular mechanisms.|Antineoplastic Agents/*metabolism[MESH]|Bifidobacterium/*physiology[MESH]|Female[MESH]|Humans[MESH]|Lactococcus/*physiology[MESH]|Male[MESH]|Neoplasms/*prevention & control[MESH] |