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Blurring the boundary: the nuclear envelope extends its reach Stewart CL; Roux KJ; Burke BScience 2007[Nov]; 318 (5855): 1408-12The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.|Animals[MESH]|Cytoplasm/physiology/ultrastructure[MESH]|Cytoskeleton/parasitology/physiology/ultrastructure[MESH]|Genetic Diseases, Inborn/pathology/physiopathology[MESH]|Humans[MESH]|Lamins/genetics[MESH]|Mitosis[MESH]|Mutation[MESH]|Nuclear Envelope/*physiology/*ultrastructure[MESH]|Nuclear Lamina/physiology/ultrastructure[MESH]|Nuclear Pore/physiology/ultrastructure[MESH]|Signal Transduction[MESH]|Virus Diseases/metabolism/virology[MESH] |
