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Anatomical and functional development of the pre-Botzinger complex in prenatal rodents Thoby-Brisson M; Greer JJJ Appl Physiol (1985) 2008[Apr]; 104 (4): 1213-9Developmental anomalies of central respiratory neural control contribute to newborn mortality and morbidity. Elucidation of the cellular, molecular, trophic, and genetic mechanisms involved in the formation and function of respiratory nuclei during prenatal development will provide a foundation for understanding pathologies. The pre-Botzinger Complex (pre-BotC) is a specific group of neurons located in the ventrolateral medulla that is critical for respiratory rhythmogenesis. Thus it has become a major focus of research. Here, we provide an overview of current knowledge regarding the anatomical and functional emergence of the rodent pre-BotC during the prenatal period.|Animals[MESH]|Animals, Newborn/*physiology[MESH]|Female[MESH]|Fetus/anatomy & histology/*physiology[MESH]|Medulla Oblongata/embryology/physiology[MESH]|Mice[MESH]|Nerve Net/embryology/physiology[MESH]|Pregnancy[MESH]|Rats[MESH]|Respiratory Center/anatomy & histology/*physiology[MESH]|Respiratory Mechanics/physiology[MESH]|Respiratory System/anatomy & histology/*embryology[MESH] |
