Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Evaluation of PDE4 inhibition for COPD Wang D; Cui XInt J Chron Obstruct Pulmon Dis 2006[]; 1 (4): 373-9Targeting type 4 phosphodiesterase (PDE4) for treatment of COPD has multilevel benefits to patients by reducing inflammation, relieving bronchoconstriction, and improving pulmonary circulation. The isoenzyme-specific narrow spectrum PDE4 inhibitors such as cilomilast and roflumilast may have limited clinical efficacy in managing severe and very severe COPD. Development of dual therapy by combining PDE4 inhibition with Ca2+ channel antagonism may introduce an effective novel armory for physicians to manage patients with severe COPD.|*Phosphodiesterase 4 Inhibitors[MESH]|Aminopyridines/chemistry/*pharmacology/therapeutic use[MESH]|Benzamides/chemistry/*pharmacology/therapeutic use[MESH]|Calcium Channel Blockers/*pharmacology/therapeutic use[MESH]|Carboxylic Acids/chemistry/pharmacology/therapeutic use[MESH]|Cyclohexanecarboxylic Acids[MESH]|Cyclopropanes/chemistry/pharmacology/therapeutic use[MESH]|Humans[MESH]|Nitriles/chemistry/*pharmacology/therapeutic use[MESH]|Phosphodiesterase Inhibitors/*pharmacology[MESH]|Pulmonary Circulation/drug effects[MESH]|Pulmonary Disease, Chronic Obstructive/*drug therapy[MESH]|Severity of Illness Index[MESH] |