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lüll Pregabalin: its pharmacology and use in pain management Gajraj NMAnesth Analg 2007[Dec]; 105 (6): 1805-15Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha2-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.|Animals[MESH]|Disease Management[MESH]|Humans[MESH]|Pain/*drug therapy/metabolism[MESH]|Pregabalin[MESH]|gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology/therapeutic use[MESH] |