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lüll Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry Wenzel SC; Muller RNat Prod Rep 2007[Dec]; 24 (6): 1211-24Over the last 20 years myxobacteria have made their way from highly exotic organisms to one of the major sources of microbial natural products with interesting biological activities. Recent progress towards achieving a better understanding of the genetics and the biochemistry of myxobacterial secondary metabolism, revealed the involvement of numerous exceptional combinations of polyketide synthases and nonribosomal peptide synthetases operating far from textbook biosynthetic logic. In this Highlight, selected examples of recently described systems are discussed in comparison to all myxobacterial natural product assembly lines known to date.|*Biological Products/biosynthesis/chemistry/isolation & purification[MESH]|*Myxococcales/chemistry/genetics/metabolism[MESH]|Biochemical Phenomena[MESH]|Biochemistry[MESH]|Models, Biological[MESH]|Molecular Structure[MESH]|Peptide Synthases/*metabolism[MESH]|Polyketide Synthases/*metabolism[MESH] |