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Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes Veillette A; Dong Z; Latour SImmunity 2007[Nov]; 27 (5): 698-710Signaling lymphocytic activation molecule (SLAM) family receptors mediate important regulatory signals in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors. As discussed herein, recent findings show that the SLAM and SAP families carry out pivotal functions in innate-like and conventional lymphocytes. They are critically needed for the development of innate-like lymphocytes such as NKT cells. In addition, they influence several of the functions of conventional lymphocytes, including the ability of CD4(+) T cells to secrete certain cytokines and mediate B cell help; CD8(+) T cell proliferation and cytokine production; NK cell-mediated cytotoxicity; and B cell antibody production. These unique functional properties appear to be facilitated by the ability of SLAM-related receptors to serve as self-ligands during homotypic interactions between immune cells. The importance of the SLAM-SAP pathway in normal immunity is highlighted by the finding that SAP is mutated in humans suffering from the immunodeficiency X-linked lymphoproliferative disease.|Animals[MESH]|Antigens, CD/*immunology/metabolism[MESH]|Cell Differentiation/*immunology[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/*immunology/metabolism[MESH]|Lymphocyte Activation/immunology[MESH]|Receptors, Cell Surface/*immunology/metabolism[MESH]|Signal Transduction/*immunology[MESH]|Signaling Lymphocytic Activation Molecule Associated Protein[MESH]|Signaling Lymphocytic Activation Molecule Family Member 1[MESH]|T-Lymphocytes/cytology/*immunology[MESH]|X-Linked Combined Immunodeficiency Diseases/*immunology[MESH]|X-Linked Inhibitor of Apoptosis Protein/immunology[MESH] |
