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lüll CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use Mottet C; Golshayan DSwiss Med Wkly 2007[Nov]; 137 (45-46): 625-34Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.|Animals[MESH]|Antigens, CD/immunology[MESH]|Antigens, Differentiation/immunology[MESH]|CTLA-4 Antigen[MESH]|Forkhead Transcription Factors/immunology/*physiology/therapeutic use[MESH]|Humans[MESH]|Immune Tolerance/physiology[MESH]|Interleukin-10/immunology/physiology[MESH]|Interleukin-2/immunology/physiology[MESH]|Receptors, Interleukin-2/immunology/physiology[MESH]|T-Lymphocytes, Regulatory/immunology/*physiology[MESH]|Transforming Growth Factor beta/immunology/physiology[MESH]|Transplantation Immunology[MESH] |