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  • CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use
  • Mottet C; Golshayan D
  • Swiss Med Wkly 2007[Nov]; 137 (45-46): 625-34
  • Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
  • |Animals[MESH]
  • |Antigens, CD/immunology[MESH]
  • |Antigens, Differentiation/immunology[MESH]
  • |CTLA-4 Antigen[MESH]
  • |Forkhead Transcription Factors/immunology/*physiology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immune Tolerance/physiology[MESH]
  • |Interleukin-10/immunology/physiology[MESH]
  • |Interleukin-2/immunology/physiology[MESH]
  • |Receptors, Interleukin-2/immunology/physiology[MESH]
  • |T-Lymphocytes, Regulatory/immunology/*physiology[MESH]
  • |Transforming Growth Factor beta/immunology/physiology[MESH]
  • |Transplantation Immunology[MESH]





  • *{{pmid18027108}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=18027108 CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use ]</b> Swiss Med Wkly 2007; 137(45-46) ; 625-34 Mottet C; Golshayan D

        *18027108*

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    Swiss Med Wkly

    625 45-46.137 2007