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Allopeptides and the alloimmune response Bharat A; Mohanakumar TCell Immunol 2007[Jul]; 248 (1): 31-43The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.|*Antigen Presentation[MESH]|*Immune Tolerance[MESH]|Animals[MESH]|Graft Rejection/*immunology/prevention & control[MESH]|Graft Survival/*immunology[MESH]|Heart Transplantation[MESH]|Histocompatibility Antigens[MESH]|Humans[MESH]|Immunosuppressive Agents/immunology/pharmacology[MESH]|Isoantigens/*immunology/pharmacology[MESH]|Kidney Transplantation[MESH]|Lymphocyte Activation/drug effects/*immunology[MESH]|Mice[MESH]|Models, Animal[MESH]|Peptides/chemical synthesis/*immunology/pharmacology[MESH]|Rats[MESH]|Rats, Inbred Lew[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|Thymus Gland/immunology[MESH]|Transplantation Immunology[MESH]|Transplantation, Homologous[MESH] |
