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lüll The lipin protein family: dual roles in lipid biosynthesis and gene expression Reue K; Zhang PFEBS Lett 2008[Jan]; 582 (1): 90-6The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 alpha and PPAR alpha. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.|Adipocytes/cytology[MESH]|Adipose Tissue/metabolism[MESH]|Animals[MESH]|Gene Expression Regulation/*genetics[MESH]|Humans[MESH]|Insulin Resistance[MESH]|Lipids/*biosynthesis[MESH]|Liver/metabolism[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Nuclear Proteins/genetics/*physiology[MESH]|Phosphatidate Phosphatase/metabolism[MESH]|Phosphorylation[MESH]|Transcription, Genetic[MESH] |