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Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments Tanabe K; Zhang Z; Ito T; Hatta H; Nishimoto SOrg Biomol Chem 2007[Dec]; 5 (23): 3745-57To address the specific challenges of cancer therapy and diagnosis, a number of approaches have been advocated for the development of tumor-targeting antitumor drugs/prodrugs and non-invasive tumor molecular imaging probes. These intelligent drugs and probes are constructed from multi-functional molecular systems. This review focuses on the molecular design of drugs and imaging probes that target tumor-specific microenvironments such as angiogenesis and hypoxia.|*Drug Design[MESH]|*Molecular Probes[MESH]|Antineoplastic Agents/pharmacology/therapeutic use[MESH]|Blood Vessels/drug effects[MESH]|Neoplasms/blood supply[MESH]|Prodrugs/pharmacology/therapeutic use[MESH] |
