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lüll Wnt/beta-catenin signaling in adipogenesis and metabolism Prestwich TC; Macdougald OACurr Opin Cell Biol 2007[Dec]; 19 (6): 612-7Adipocyte differentiation consists of a complex series of events in which scores of cellular and extracellular factors interact to transform a fibroblast-like preadipocyte into a mature, lipid-filled adipocyte. Many of the pathways influencing this process have been identified using well-characterized preadipocyte culture systems and have subsequently been confirmed in animal models. Research conducted over the past decade has established the Wnt/beta-catenin signaling pathway as an important regulator of adipocyte differentiation. While initial reports implicated activators of Wnt/beta-catenin signaling as potent inhibitors of adipogenesis, recent investigations of mesenchymal cell fate, obesity, and type 2 diabetes highlight significant additional roles for Wnt signaling in metabolism and adipocyte biology.|Adipogenesis/*physiology[MESH]|Adipose Tissue/*metabolism[MESH]|Animals[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Signal Transduction/*physiology[MESH]|Wnt Proteins/*physiology[MESH]|beta Catenin/*physiology[MESH] |