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Trafficking and cellular distribution of voltage-gated sodium channels Cusdin FS; Clare JJ; Jackson APTraffic 2008[Jan]; 9 (1): 17-26Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.|Animals[MESH]|Cell Membrane/metabolism[MESH]|Humans[MESH]|Myocytes, Cardiac/metabolism[MESH]|Neurons/metabolism[MESH]|Protein Transport[MESH]|Sodium Channels/*metabolism[MESH] |
