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lüll Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy Plummer ER; Calvert HClin Cancer Res 2007[Nov]; 13 (21): 6252-6The DNA repair pathways are protective of the host genome in normal cells; however, in cancer cells, these pathways may be disrupted and predispose to tumorigenesis or their activity may overcome the potentially cytotoxic damage caused by anticancer agents and be a mechanism of resistance. Poly(ADP-ribose) polymerase inhibitors, which block base excision repair of single-strand breaks, have entered the clinic in the last few years. This article discusses the interactions between the pathways of single- and double-strand break repair, which explain the two clinical development strategies for this class of drugs.|Animals[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Binding Sites[MESH]|DNA Damage[MESH]|DNA Repair[MESH]|Genome[MESH]|Genome, Human[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/*enzymology/metabolism/*pathology/*therapy[MESH]|Poly(ADP-ribose) Polymerases/*metabolism[MESH] |