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lüll Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance Gomes AQ; Correia DV; Silva-Santos BEMBO Rep 2007[Nov]; 8 (11): 1024-30Tumours develop in vertebrate organisms endowed with immune systems that are potentially able to eradicate them. Nevertheless, our ever-increasing understanding of the complex interactions between lymphocytes and tumour cells fuels the long-standing hope of developing efficient immunotherapies against cancer. This review focuses on a versatile family of proteins, the major histocompatibility complex class Ib, which has been recently implicated in both the establishment of anti-tumour immune responses and in tumour immune response evasion. We focus on a subset of class Ib proteins, human leukocyte antigen (HLA)-G, Qa-2, CD1d and NKG2D ligands, which bind to either stimulatory or inhibitory receptors expressed on T, natural killer (NK) and NKT lymphocytes, and thereby modulate their anti-tumour activity.|*Major Histocompatibility Complex[MESH]|*Monitoring, Immunologic[MESH]|Animals[MESH]|Antigen Presentation[MESH]|Antigens, CD1/immunology[MESH]|Antigens, CD1d[MESH]|HLA Antigens/*immunology[MESH]|HLA-G Antigens[MESH]|Histocompatibility Antigens Class I/*immunology[MESH]|Humans[MESH]|Killer Cells, Natural/immunology[MESH]|Lipids/immunology[MESH]|NK Cell Lectin-Like Receptor Subfamily K[MESH]|Neoplasms/*immunology[MESH]|Peptides/immunology[MESH]|Receptors, Immunologic/immunology[MESH]|Receptors, Natural Killer Cell[MESH]|T-Lymphocytes/immunology[MESH] |