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On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme Jeltsch AEpigenetics 2006[Apr]; 1 (2): 63-6In this short review the enzymatic properties of Dnmt1 are summarized. Studies on the specificity of Dnmt1 have shown that it has 30-40 fold preference for hemimethylated target sites. It methylates hemimethylated DNA in a processive reaction, moving on the DNA in a random walk. Binding of DNA to allosteric site(s) in the N-terminal part of the enzyme can lead to stimulation and inhibition of its catalytic activity depending on the nature of the substrate and effector.|*Allosteric Regulation[MESH]|Binding Sites[MESH]|Catalysis[MESH]|DNA Methylation[MESH]|Diffusion[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Models, Biological[MESH]|Repressor Proteins/*metabolism[MESH]|Substrate Specificity[MESH] |
