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lüll Clinical strategies to enhance T cell reconstitution Goldberg GL; Zakrzewski JL; Perales MA; van den Brink MRSemin Immunol 2007[Oct]; 19 (5): 289-96Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.|Fibroblast Growth Factor 7/pharmacology[MESH]|Gonadal Steroid Hormones/physiology[MESH]|Growth Hormone/pharmacology[MESH]|Hematopoietic Stem Cells/physiology[MESH]|Humans[MESH]|Interleukin-7/pharmacology[MESH]|T-Lymphocytes/*physiology[MESH] |