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The renal safety of bowel preparations for colonoscopy: a comparative study of oral sodium phosphate solution and polyethylene glycol Singal AK; Rosman AS; Post JB; Bauman WA; Spungen AM; Korsten MAAliment Pharmacol Ther 2008[Jan]; 27 (1): 41-7BACKGROUND: Rare cases of nephrotoxicity have been reported with oral sodium phosphate solution (OSPS). AIM: To evaluate whether OSPS is associated with changes in renal function. METHODS: A chart review performed on 311 patients who had colonoscopy at the James J. Peters VA Medical Centre prepared with either OSPS (n = 157) or polyethylene glycol (PEG) (n = 154). Patients had a baseline serum creatinine or=50% increase above their baseline creatinine was similar (OSPS vs. PEG, 5% vs. 3%, P = 0.77). CONCLUSIONS: Oral sodium phosphate solution was associated with a slight increase in serum creatinine, which was not clinically significant. Renal toxicity from OSPS appears to be minimal when used in patients with serum creatinine value <1.5 mg/dL.|Acute Kidney Injury/chemically induced[MESH]|Aged[MESH]|Cathartics/*adverse effects[MESH]|Colonoscopy/*adverse effects/methods[MESH]|Creatinine/blood[MESH]|Female[MESH]|Humans[MESH]|Kidney/*drug effects[MESH]|Male[MESH]|Middle Aged[MESH]|Phosphates/administration & dosage/*adverse effects[MESH]|Polyethylene Glycols/*adverse effects[MESH]|Regression Analysis[MESH]|Retrospective Studies[MESH]|Therapeutic Irrigation[MESH] |
