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lüll Dementia pugilistica with clinical features of Alzheimer s disease Areza-Fegyveres R; Rosemberg S; Castro RM; Porto CS; Bahia VS; Caramelli P; Nitrini RArq Neuropsiquiatr 2007[Sep]; 65 (3B): 830-3A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease.|Alzheimer Disease/*diagnosis[MESH]|Boxing/*injuries[MESH]|Brain/*pathology[MESH]|Dementia/diagnosis/*etiology/pathology[MESH]|Diagnosis, Differential[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Male[MESH]|Middle Aged[MESH] |