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Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation Kostova Z; Tsai YC; Weissman AMSemin Cell Dev Biol 2007[Dec]; 18 (6): 770-9Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action.|Animals[MESH]|Endoplasmic Reticulum/*metabolism[MESH]|Humans[MESH]|Mammals[MESH]|Proteins/metabolism[MESH]|Saccharomyces cerevisiae Proteins[MESH]|Ubiquitin-Protein Ligases/*metabolism[MESH]|Ubiquitination[MESH] |
