Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis Benjamin JM; Nelson WJSemin Cancer Biol 2008[Feb]; 18 (1): 53-64The cadherin/catenin complex, comprised of E-cadherin, beta-catenin and alpha-catenin, is essential for initiating cell-cell adhesion, establishing cellular polarity and maintaining tissue organization. Disruption or loss of the cadherin/catenin complex is common in cancer. As the primary cell-cell adhesion protein in epithelial cells, E-cadherin has long been studied in cancer progression. Similarly, additional roles for beta-catenin in the Wnt signaling pathway has led to many studies of the role of beta-catenin in cancer. Alpha-catenin, in contrast, has received less attention. However, recent data demonstrate novel functions for alpha-catenin in regulating the actin cytoskeleton and cell-cell adhesion, which when perturbed could contribute to cancer progression. In this review, we use cancer data to evaluate molecular models of alpha-catenin function, from the canonical role of alpha-catenin in cell-cell adhesion to non-canonical roles identified following conditional alpha-catenin deletion. This analysis identifies alpha-catenin as a prognostic factor in cancer progression.|*Cell Adhesion[MESH]|Actin Cytoskeleton/*physiology[MESH]|Actins/*metabolism[MESH]|Animals[MESH]|Apoptosis[MESH]|Cadherins/metabolism[MESH]|Cell Polarity[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins/metabolism[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/*metabolism/pathology/*physiopathology[MESH]|Signal Transduction[MESH]|alpha Catenin/*metabolism[MESH]|beta Catenin/metabolism[MESH] |