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lüll CD147 immunoglobulin superfamily receptor function and role in pathology Iacono KT; Brown AL; Greene MI; Saouaf SJExp Mol Pathol 2007[Dec]; 83 (3): 283-95The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced.|Alzheimer Disease/metabolism/physiopathology[MESH]|Animals[MESH]|Basigin/chemistry/genetics/*metabolism[MESH]|Caveolin 1/metabolism[MESH]|Cyclophilins/metabolism[MESH]|Disease Progression[MESH]|Humans[MESH]|Hypoxia[MESH]|Integrins/metabolism[MESH]|Ischemia/metabolism/physiopathology[MESH]|Lymphocytes/metabolism[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Monocarboxylic Acid Transporters/metabolism[MESH]|Neoplasms/metabolism/pathology/physiopathology[MESH] |