Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17898100&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Evidence of MEN-2 in the original description of classic pheochromocytoma Neumann HP; Vortmeyer A; Schmidt D; Werner M; Erlic Z; Cascon A; Bausch B; Januszewicz A; Eng CN Engl J Med 2007[Sep]; 357 (13): 1311-5The first description of pheochromocytoma in 1886 has been attributed to Felix Frankel, who described an 18-year-old woman with bilateral adrenal "sarcoma and angio-sarcoma." We reviewed the publication and then approached and assessed relatives of the patient to update the findings with the use of current technology. In-depth review revealed that the histopathological findings were consistent with pheochromocytoma. Because the proband was young and had bilateral disease at diagnosis, we hypothesized that she had an inherited condition. The presence of germ-line RET mutations in four living relatives demonstrates that the original patient and her family had multiple endocrine neoplasia type 2 and provides molecular evidence that she had pheochromocytoma.|*Germ-Line Mutation[MESH]|Adrenal Gland Neoplasms/genetics/*history[MESH]|Carcinoma, Medullary/genetics[MESH]|DNA Mutational Analysis[MESH]|Female[MESH]|History, 19th Century[MESH]|Humans[MESH]|Male[MESH]|Multiple Endocrine Neoplasia Type 2a/*genetics/history[MESH]|Pedigree[MESH]|Pheochromocytoma/genetics/*history[MESH]|Thyroid Neoplasms/genetics[MESH] |
