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20 years of RET/PTC in thyroid cancer: clinico-pathological correlations Fusco A; Santoro MArq Bras Endocrinol Metabol 2007[Jul]; 51 (5): 731-5The RET/PTC oncogene has been isolated almost twenty years ago. During these years, the research has given a final answer to several questions. In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET/PTC activation is essentially restricted to the papillary histotype and to the Hurthle thyroid tumors; c) its incidence increases after exposure to radiations. However, some questions have not found a final answer yet: a) which is the real frequency of RET/PTC activation? Likely it is around 20%, but this point is still questionable; b) which other gene modifications are required to lead a thyroid cell carrying a RET/PTC oncogene to the malignant phenotype?, and c) is there any correlation between RET/PTC activation and clinical parameters? We hope that these questions will have a clear answer in the near future.|*Gene Rearrangement[MESH]|Adenoma, Oxyphilic/*genetics/pathology[MESH]|Animals[MESH]|Australia[MESH]|Canada[MESH]|Carcinoma, Papillary/*genetics/pathology[MESH]|Hashimoto Disease/genetics[MESH]|Humans[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Neoplasms, Radiation-Induced/genetics[MESH]|Oncogene Proteins, Fusion/*genetics[MESH]|Protein-Tyrosine Kinases/*genetics[MESH]|Proto-Oncogene Proteins c-ret/genetics[MESH]|Thyroid Neoplasms/*genetics/pathology[MESH]|Time Factors[MESH]|Transcriptional Activation[MESH]|United States[MESH] |
