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lüll The Tritope Model for restrictive recognition of antigen by T-cells II Implications for ontogeny, evolution and physiology Cohn MMol Immunol 2008[Feb]; 45 (3): 632-52Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, "nonclassical" MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted.|*Evolution, Molecular[MESH]|*Models, Immunological[MESH]|Animals[MESH]|Antigen Presentation/*physiology[MESH]|Antigens/*immunology[MESH]|Humans[MESH]|T-Lymphocytes, Helper-Inducer/*physiology[MESH] |