suck pdf from google scholar
unlimited free pdf from europmc17888627    free
PDF from PMC    free
html from PMC    free
PDF vom PMID17888627  :  Publisher
PDF vom PMID17888627
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • Innate and adaptive immune response to apoptotic cells
  • Peng Y; Martin DA; Kenkel J; Zhang K; Ogden CA; Elkon KB
  • J Autoimmun 2007[Dec]; 29 (4): 303-9
  • The immune system is constantly exposed to dying cells, most of which arise during central tolerance and from effete circulating immune cells. Under homeostatic conditions, phagocytes (predominantly macrophages and dendritic cells) belonging to the innate immune system, rapidly ingest cells and their debris. Apoptotic cell removal requires recognition of altered self on the apoptotic membrane, a process which is facilitated by natural antibodies and serum opsonins. Recognition, may be site and context specific. Uptake and ingestion of apoptotic cells promotes an immunosuppressive environment that avoids inflammatory responses to self-antigens. However, it does not preclude a T cell response and it is likely that constant exposure to self-antigen, particularly by immature dendritic cells, leads to T cell tolerance. Tolerance occurs by several different mechanisms including anergy and deletion (for CD8+T cells) and induction of T regulatory cells (for CD4+T cells). Failed apoptotic cell clearance promotes immune responses to self-antigens, especially when the cellular contents are leaked from the cell (necrosis). Inflammatory responses may be induced by nucleic acid stimulation of Toll like receptors and other immune sensors, specific intracellular proteins and non-protein (uric acid) stimulation of inflammasomes.
  • |*Immune Tolerance[MESH]
  • |*Immunity, Innate[MESH]
  • |*Models, Immunological[MESH]
  • |Animals[MESH]
  • |Apoptosis/*immunology[MESH]
  • |Autoantigens/immunology[MESH]
  • |Humans[MESH]

  • *{{pmid17888627}}
    *<b>[ Innate and adaptive immune response to apoptotic cells ]</b> J Autoimmun 2007; 29(4) ; 303-9 Peng Y; Martin DA; Kenkel J; Zhang K; Ogden CA; Elkon KB


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    J Autoimmun

    303 4.29 2007