Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The RASSF1A tumor suppressor Donninger H; Vos MD; Clark GJJ Cell Sci 2007[Sep]; 120 (Pt 18): 3163-72RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigenetic mechanism can inactivate numerous tumor suppressors and is now recognized as a major contributor to the development of cancer. RASSF1A lacks apparent enzymatic activity but contains a Ras association (RA) domain and is potentially an effector of the Ras oncoprotein. RASSF1A modulates multiple apoptotic and cell cycle checkpoint pathways. Current evidence supports the hypothesis that it serves as a scaffold for the assembly of multiple tumor suppressor complexes and may relay pro-apoptotic signaling by K-Ras.|*Apoptosis[MESH]|*Cell Cycle[MESH]|*DNA Methylation[MESH]|*Gene Silencing[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Epigenesis, Genetic[MESH]|Gene Deletion[MESH]|Humans[MESH]|Neoplasms/genetics/metabolism[MESH]|Point Mutation[MESH]|Protein Binding/genetics[MESH]|Protein Structure, Tertiary/genetics[MESH]|Tumor Suppressor Proteins/genetics/*metabolism[MESH]|ras Proteins/genetics/metabolism[MESH] |
