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SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma Comar M; Rizzardi C; de Zotti R; Melato M; Bovenzi M; Butel JS; Campello CCancer Res 2007[Sep]; 67 (18): 8456-9To assess the presence of SV40 in malignant mesothelioma tissue, 19 formalin-fixed paraffin-embedded pleural cancer samples of patients from a hyperendemic area of northeastern Italy were analyzed retrospectively. A total of 48 other tissues from the malignant mesothelioma subjects were investigated. The SV40 load was determined by real-time quantitative PCR. Exposure to asbestos was evaluated through a careful review of the occupational history of patients, supplemented by histology and isolation of asbestos bodies. Three of 19 (15.8%) malignant mesothelioma tissues harbored SV40 genomic signals. Two patients with SV40-positive malignant mesothelioma had viral sequences in another tissue. Overall, 3 of 18 (16.7%) normal liver tissues tested positive for SV40, as did 1 of 8 (12.5%) kidney tissues. SV40 viral loads were higher in malignant mesothelioma than in normal cells (P = 0.045). This survey shows that SV40 sustains infections in multiple tissues in malignant mesothelioma patients from a geographic area affected with asbestos-related mesothelioma.|*Cocarcinogenesis[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Asbestos/*adverse effects[MESH]|DNA, Viral/genetics[MESH]|Endemic Diseases[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Mesothelioma/epidemiology/*etiology/virology[MESH]|Middle Aged[MESH]|Pleural Neoplasms/epidemiology/*etiology/virology[MESH]|Polymerase Chain Reaction[MESH]|Polyomavirus Infections/*complications/virology[MESH]|Retrospective Studies[MESH]|Simian virus 40/*genetics[MESH]|Tumor Virus Infections/*complications/virology[MESH] |
