Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2 Lewis CE; De Palma M; Naldini LCancer Res 2007[Sep]; 67 (18): 8429-32Recent findings indicate that tumor-associated macrophages are important drivers of tumor angiogenesis. Here, we review the essential role played by Tie2-expressing monocytes (TEM) in this phenomenon. TEMs are present in human blood and tumors and their elimination in various tumor models suppresses tumor angiogenesis. A ligand for Tie2, angiopoietin-2 (Ang-2), is produced by angiogenic tumor vessels and is a chemoattractant for TEMs. Hypoxia up-regulates Tie2 expression on TEMs and, together with Ang-2, down-regulates their antitumor functions. Learning more about the regulation of TEMs by the tumor microenvironment may yield new strategies to ablate the tumor vasculature.|Angiopoietin-2/biosynthesis/genetics/*metabolism[MESH]|Animals[MESH]|Cell Hypoxia[MESH]|Humans[MESH]|Monocytes/*enzymology[MESH]|Neoplasms/blood/*blood supply/*enzymology/genetics[MESH]|Neovascularization, Pathologic/blood/enzymology[MESH]|Receptor, TIE-2/*biosynthesis/genetics[MESH]|Up-Regulation[MESH] |