Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Mixed lineage leukemia translocations and a leukemia stem cell program Faber J; Armstrong SACancer Res 2007[Sep]; 67 (18): 8425-8Cancer stem cells (CSC) may provide the self-renewal capacity required to sustain a tumor. One possibility is that CSC arise from the stem cell counterparts in normal tissues. Alternatively, CSC may arise from more differentiated progenitor cells found in certain tissues. In support of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert committed hematopoietic progenitors into leukemias, which include leukemia stem cells expressing a self-renewal associated program in the context of a differentiated myeloid cell. The findings suggest a basis to understand the pathobiology of CSC and possible strategies to attack them to undermine the self-renewal capacity of a tumor.|Animals[MESH]|Cell Transformation, Neoplastic/genetics/metabolism/pathology[MESH]|Hematopoietic Stem Cells/*pathology[MESH]|Humans[MESH]|Leukemia, Biphenotypic, Acute/genetics/metabolism/*pathology[MESH]|Neoplastic Stem Cells/*pathology[MESH]|Oncogene Proteins, Fusion/biosynthesis/genetics[MESH]|Translocation, Genetic[MESH] |