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Glucose tolerance abnormalities in Australian women with polycystic ovary syndrome Dabadghao P; Roberts BJ; Wang J; Davies MJ; Norman RJMed J Aust 2007[Sep]; 187 (6): 328-31OBJECTIVES: To determine the prevalence of glucose tolerance abnormalities and to identify associated risk factors in women with polycystic ovary syndrome (PCOS) attending a reproductive endocrinology clinic. DESIGN: Retrospective chart review. PARTICIPANTS AND SETTING: 372 women with confirmed PCOS attending a reproductive endocrinology clinic at Adelaide University's Research Centre for Reproductive Health. MAIN OUTCOME MEASURES: Prevalence of glucose tolerance abnormalities and association of such abnormalities with potential risk factors. RESULTS: 4.0% (15 women) had diabetes mellitus, 15.6% (58) had impaired glucose tolerance and 80.4% (299) had normal glucose tolerance. There was a significant trend towards increasing prevalence of diabetes with increasing age (odds ratio [OR], 0.60; P = 0.0085). The prevalence of abnormal glucose tolerance (diabetes and impaired glucose tolerance together) was significantly higher with higher waist circumference (OR, 2.9; P = 0.05), higher body mass index (OR, 8.02; P = 0.0253), a family history of diabetes (OR, 1.56; P = 0.0192) and the presence of metabolic syndrome (OR, 5.62; P < 0.001). CONCLUSION: The prevalence of diabetes and impaired glucose tolerance is high in women with PCOS, especially in older women and those with abdominal obesity and a family history of diabetes.|Adolescent[MESH]|Adult[MESH]|Diabetes Complications[MESH]|Female[MESH]|Glucose Intolerance/complications[MESH]|Glucose Tolerance Test[MESH]|Glucose/*metabolism[MESH]|Humans[MESH]|Middle Aged[MESH]|Polycystic Ovary Syndrome/*metabolism[MESH]|Retrospective Studies[MESH] |
