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lüll Pulmonary hypertension in idiopathic pulmonary fibrosis Patel NM; Lederer DJ; Borczuk AC; Kawut SMChest 2007[Sep]; 132 (3): 998-1006Idiopathic pulmonary fibrosis (IPF) is an untreatable diffuse parenchymal lung disease with a median survival of < 3 years. Pulmonary hypertension (PH) is frequently seen in patients with IPF and is commonly attributed to hypoxic vasoconstriction and capillary destruction. Pathology findings include endothelial proliferation and medial hypertrophy that exceed those expected in the setting of hypoxia. Noninvasive evaluation has limited sensitivity and specificity for the diagnosis of PH in IPF; therefore, right-heart catheterization remains the "gold standard" diagnostic test. PH in patients with IPF is associated with decreased exercise capacity and worse survival. Given the grave consequences of this condition, treatment of PH could improve functional outcomes and survival. However, possible treatments such as long-term supplemental oxygen and targeted vascular therapy are either unstudied or remain unproven.|*Hypertension, Pulmonary/diagnosis/epidemiology/physiopathology[MESH]|Humans[MESH]|Pulmonary Fibrosis/*complications[MESH]|Respiratory Function Tests[MESH]|Survival Rate[MESH] |