Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Leptin signaling and obesity: cardiovascular consequences Yang R; Barouch LACirc Res 2007[Sep]; 101 (6): 545-59Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on multiple organ systems. In this review, we summarize major leptin signaling pathways, namely Janus-activated kinase/signal transducers and activators of transcription and mitogen-activated protein kinase, including possible mechanisms of leptin resistance in obesity. The effects of leptin on the cardiovascular system are discussed in detail, including its contributions to hypertension, atherosclerosis, depressed myocardial contractile function, fatty acid metabolism, hypertrophic remodeling, and reduction of ischemic/reperfusion injury. The overall goal is to summarize current understanding of how altered leptin signaling in obesity contributes to obesity-related cardiovascular disease.|*Signal Transduction/drug effects[MESH]|Animals[MESH]|Cardiovascular Diseases/*etiology/metabolism/physiopathology[MESH]|Cardiovascular System/metabolism/physiopathology[MESH]|Central Nervous System/metabolism/physiopathology[MESH]|Hormone Antagonists/pharmacology[MESH]|Humans[MESH]|Leptin/antagonists & inhibitors/*metabolism[MESH]|Obesity/complications/*metabolism/physiopathology[MESH]|Risk Factors[MESH] |